Patologia i Terapèutica Experimental: Recent submissions
Now showing items 21-40 of 1064
A urine-based DNA methylation assay, ProCUrE, to identify clinically significant prostate cancer
Background: prevention of unnecessary biopsies and overtreatment of indolent disease remains a challenge in the management of prostate cancer. Novel non-invasive tests that can identify clinically significant (intermediate-risk ...
Docencia sobre las fuentes comerciales de información de medicamentos y opinión de los estudiantes de medicina
Objetivo: Conocer la opinión de los estudiantes sobre un seminario que enseña la interacción de los médicos con las fuentes comerciales de información de los medicamentos. Sujetos y métodos: Se realizó una encuesta a los ...
Exocytosis at the ribbon synapse of retinal bipolar cells studied in patches of presynaptic membrane
The distribution of exocytic sites and ion channels in the synaptic terminal of retinal bipolar cells was investigated by measuring capacitance and conductance changes in cell-attached patches of presynaptic membrane. Patch ...
Bacterial membrane injuries induced by lactacin F and nisin
The combined action of nisin and lactacin F, two bacteriocins produced by lactic acid bacteria, is additive. In this report, the basis of this effect is examined. Channels formed by lactacin F were studied by experiments ...
Telomere length shows no association with BRCA1 and BRCA2 mutation status
This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 ...
Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation.
In murine macrophages, as a result of arginine catabolism during activation, citruline isproduced under the effect of IFN-c and LPS, and ornithine and polyamines by IL-4 and IL-10. For proliferation, arginine is required ...
Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an ...
Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology
Synaptic dysfunction is an early feature in Alzheimer's disease (AD) pathogenesis and a major morphological correlate of memory deficits. Given the main synaptic location of N-methyl-D-aspartate receptors (NMDARs), their ...
Percutaneous, intra-articular, Chevron osteotomy (PeICO) for the treatment of hallux valgus: a cadaveric study
Background: Percutaneous surgery is experiencing sustained growth based on third-generation techniques. This cadaveric study was designed with the main goal of exploring the risk of iatrogenic tendon and neurovascular ...
Expressió gènica en models d'isquèmia cerebral
La isquèmia cerebral pot causar una lesió irreversible al cervell, amb una important pèrdua neuronal a les zones afectades. Entre els primers canvis que es detecten després de la isquèmia hi ha alteracions del patró ...
Feasibility of lumbar puncture in the study of cerebrospinal fluid biomarkers for Alzheimer disease in subjects with Down syndrome
Background: Alzheimer's disease (AD) is the main medical problem in older adults with Down syndrome (DS). Studies of cerebrospinal fluid (CSF) AD biomarkers are limited and the feasibility of lumbar puncture (LP) is ...
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
Background: the TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide ...
Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells
Melanoma is one of the most aggressive types of skin cancer and its incidence rate is still increasing. All existing treatments are minimally effective. Consequently, new therapeutic agents for melanoma treatment should ...
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for modeling neurological diseases. However, iPSC models are fraught with technical limitations including abnormal aggregation and inefficient ...
miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy
The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number of menstrual cycles and pregnancy (in this case transiently) ...
Percutaneous flexor digitorum brevis tenotomy: An anatomical study.
Introduction: A percutaneous selective flexor digitorum brevis (FDB) tenotomy and a proximal interphalangeal (PIP) joint arthrolysis may correct a lesser claw toe deformity keeping flexor digitorum longus (FDL) and active ...
High-potency ligands for DREADD imaging and activation in rodents and monkeys
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well. ...
Selection of intraoperative tasks for awake mapping based on relationships between tumor location and functional networks
Intraoperative electrical brain mapping is currently the most reliable method to identify eloquent cortical and subcortical structures at the individual level and to optimize the extent of resection of intrinsic brain ...
Adquisición de habilidades para la investigación
Introducción. En el curso 2010-11, se implementó la asignatura obligatoria de Farmacología (6 créditos) para el segundo curso del Grado de Podología. Debido a que la obtención del título de grado permite a los alumnos ...
Benznidazole nanoformulates: a chance to improve therapeutics for Chagas disease
This article describes the characterization of various encapsulated formulations of benznidazole, the current first-line drug for the treatment of Chagas disease. Given the adverse effects of benznidazole, safer formulations ...
