A Novel Generation of Tailored Antimicrobial Drugs Based on Recombinant Multidomain Proteins 

    López-Cano, Adrià; Ferrer-Miralles, Neus; Sánchez, Julieta; Carratalá, Jose Vicente; Rodriguez Rodriguez, Xavier; Ratera, Imma; Guasch, Judith; Pich, Oscar Q.; Bierge, Paula; Garcia-de-la-Maria, Cristina; Miro, Jose M.; Garcia-Fruitos, Elena; Alomar, Oscar (2023-03-26)

    Antibiotic resistance has exponentially increased during the last years. It is necessary to develop new antimicrobial drugs to prevent and treat infectious diseases caused by multidrug- or extensively-drug resistant ...

    Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method 

    Merlo-Mas, Josep; Tomsen-Melero, Judit; Corchero, José-Luis; González-Mira, Elisabet; Font, Albert; Pedersen, Jannik N.; García-Aranda, Natalia; Cristóbal-Lecina, Edgar; Alcaina-Hernando, Marta; Mendoza, Rosa; Garcia-Fruitos, Elena; Lizarraga, Teresa; Resch, Susanne; Schimpel, Christa; Falk, Andreas; Pulido, Daniel; Royo, Miriam; Schwartz Jr., Simó; Abasolo, Ibane; Pedersen, Jan Skov; Danino, Dganit; Soldevila, Andreu; Veciana, Jaume; Sala, Santi; Ventosa, Nora; Córdoba, Alba (2021-02-19)

    Fabry disease is a lysosomal storage disease arising from a deficiency of the enzyme α-galactosidase A (GLA). The enzyme deficiency results in an accumulation of glycolipids, which over time, leads to cardiovascular, ...

    CCL21-loaded 3D hydrogels for T cell expansion and differentiation 

    Pérez del Río, Eduardo; Santos, Fabião; Rodriguez Rodriguez, Xavier; Martínez-Miguel, Marc; Roca-Pinilla, Ramon; Alomar, Oscar; Garcia-Fruitos, Elena; Veciana, Jaume; Spatz, Joachim P.; Ratera, Imma; Guasch, Judith (2020-08-13)

    Recent achievements in the field of immunotherapy, such as the development of engineered T cells used in adoptive cell therapy, are introducing more efficient strategies to combat cancer. Nevertheless, there are still many ...

    Development of a modified plug-flow anaerobic digester for biogas production from animal manures 

    Gómez, Daniel; Ramos-Suárez, Juan Luis; Fernández, Belén; Muñoz, Eduard; Tey, Laura; Romero-Güiza, Maycoll; Hansen, Felipe (2019-07-08)

    Traditional plug-flow anaerobic reactors (PFRs) are characterized by lacking a mixing system and operating at high total solid concentrations, which limits their applicability for several kinds of manures. This paper studies ...

    Evaluating Host Defense Peptides: A Comparative Analysis of Synthetic Peptides and Recombinant Concatemers 

    Saubi, Cristina; Carratalá, José Vicente; Bello-Madruga, Roberto; López-Cano, Adrià; Navarro, Susanna; Arís, Anna; Garcia-Fruitos, Elena (2025-07-08)

    The global antibiotic resistance crisis raises concerns about antibiotic use, and alternative strategies are urgently needed. In this context, host defense peptides (HDPs) have rapidly gained interest. However, one of the ...

    Genome‐wide detection of copy number variants in European autochthonous and commercial pig breeds by whole‐genome sequencing of DNA pools identified breed‐characterising copy number states 

    Bovo, S.; Ribani, A.; Muñoz, M.; Alves, E.; Araujo, J. P.; Bozzi, R.; Charneca, R.; Di Palma, F.; Etherington, G.; Fernandez, A. I.; García, F.; García‐Casco, J.; Karolyi, D.; Gallo, M.; Gvozdanović, K.; Martins, J. M.; Mercat, M. J.; Núñez, Y.; Quintanilla, R.; Radović, Č.; Razmaite, V.; Riquet, J.; Savić, R.; Schiavo, G.; Škrlep, M.; Usai, G.; Utzeri, V. J.; Zimmer, C.; Ovilo, C.; Fontanesi, L. (2020-06-08)

    In this study, we identified copy number variants (CNVs) in 19 European autochthonous pig breeds and in two commercial breeds (Italian Large White and Italian Duroc) that represent important genetic resources for this ...

    Near infrared spectroscopy for fast characterization of animal by products feedstocks for biogas production: Calibration of a handheld device 

    Otero, A.; Segura, C.; Tey, L.; Masferrer, G.; Comaposada, Josep; Fernández, Belén (2022-12-28)

    Anaerobic digestion performance is highly influenced by the chemical composition and flow of substrates. This work evaluates the feasibility of a handheld near infrared spectrometer to predict moisture, fat, and protein ...

    Opportunities and limits of combining microbiome and genome data for complex trait prediction 

    Pérez-Enciso, Miguel; Zingaretti, Laura M.; Ramayo-Caldas, Yuliaxis; de los Campos, Gustavo (2021-08-06)

    Background Analysis and prediction of complex traits using microbiome data combined with host genomic information is a topic of utmost interest. However, numerous questions remain to be answered: how useful can the ...

    Startup strategy for nitrogen removal via nitrite in a BAF system 

    Gabarró, Jordi; Guivernau, Miriam; Burgos, Laura; Garanto, Oswald; Bonmatí, August (2018-10-26)

    A biological aerated filter (BAF) pilot plant consisting of two reactors (aerobic and anoxic one) was used to determine a strategy to remove nitrogen via nitrite. RNA/DNA analysis was performed to assess microbial activity ...