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| dc.contributor.author | Sandoval, Juan |
|---|---|
| dc.contributor.author | Diaz-Lagares, Angel |
| dc.contributor.author | Salgado, Rocío |
| dc.contributor.author | Servitje Bedate, Octavio |
| dc.contributor.author | Climent, Fina |
| dc.contributor.author | Ortiz Romero, Pablo L. |
| dc.contributor.author | Pérez-Ferriols, Amparo |
| dc.contributor.author | Garcia-Muret, Maria P. |
| dc.contributor.author | Estrach Panella, Ma. Teresa (María Teresa) |
| dc.contributor.author | Garcia, Mar |
| dc.contributor.author | Nonell, Lara |
| dc.contributor.author | Esteller, Manel |
| dc.contributor.author | Pujol, Ramon M. |
| dc.contributor.author | Espinet Solà, Blanca |
| dc.contributor.author | Gallardo, Fernando |
| dc.date | 2017-05-15T12:56:26Z |
| dc.date | 2017-05-15T12:56:26Z |
| dc.date | 2015-04 |
| dc.date | 2017-05-15T12:56:26Z |
| dc.identifier | 0022-202X |
| dc.identifier | 645374 |
| dc.identifier | 25405321 |
| dc.identifier.uri | http://hdl.handle.net/2445/111029 |
| dc.description | MicroRNAs usually regulate gene expression negatively, and aberrant expression has been involved in the development of several types of cancers. Microarray profiling of microRNA expression was performed to define a microRNA signature in a series of mycosis fungoides tumor stage (MFt, n=21) and CD30+ primary cutaneous anaplastic large cell lymphoma (CD30+ cALCL, n=11) samples in comparison with inflammatory dermatoses (ID, n=5). Supervised clustering confirmed a distinctive microRNA profile for cutaneous T-cell lymphoma (CTCL) with respect to ID. A 40 microRNA signature was found in MFt including upregulated onco-microRNAs (miR-146a, miR-142-3p/5p, miR-21, miR-181a/b, and miR-155) and downregulated tumor-suppressor microRNAs (miR-200ab/429 cluster, miR-10b, miR-193b, miR-141/200c, and miR-23b/27b). Regarding CD30+ cALCL, 39 differentially expressed microRNAs were identified. Particularly, overexpression of miR-155, miR-21, or miR-142-3p/5p and downregulation of the miR-141/200c clusters were observed. DNA methylation in microRNA gene promoters, as expression regulatory mechanism for deregulated microRNAs, was analyzed using Infinium 450K array and approximately one-third of the differentially expressed microRNAs showed significant DNA methylation differences. Two different microRNA methylation signatures for MFt and CD30+ cALCL were found. Correlation analysis showed an inverse relationship for microRNA promoter methylation and microRNA expression. These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients. |
| dc.format | 10 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Society for Investigative Dermatology |
| dc.relation | Versió postprint del document publicat a: https://doi.org/10.1038/jid.2014.487 |
| dc.relation | Journal of Investigative Dermatology, 2015, vol. 135, num. 4, p. 1128-1137 |
| dc.relation | https://doi.org/10.1038/jid.2014.487 |
| dc.rights | (c) Sandoval, Juan et al., 2015 |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Micro RNAs |
| dc.subject | ADN |
| dc.subject | Metilació |
| dc.subject | Limfomes |
| dc.subject | Cèl·lules T |
| dc.subject | MicroRNAs |
| dc.subject | DNA |
| dc.subject | Methylation |
| dc.subject | Lymphomas |
| dc.subject | T cells |
| dc.title | MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/acceptedVersion |
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