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| dc.contributor.author | Mas-Stachurska, Aleksandra |
|---|---|
| dc.contributor.author | Siegert, Anna-Maria Elisa |
| dc.contributor.author | Batlle, Montserrat |
| dc.contributor.author | Gorbenko del Blanco, Darya |
| dc.contributor.author | Meirelles, Thayna |
| dc.contributor.author | Rubies, Cira |
| dc.contributor.author | Bonorino, Fabio |
| dc.contributor.author | Serra-Peinado, Carla |
| dc.contributor.author | Bijnens, Bart |
| dc.contributor.author | Baudin, Julio |
| dc.contributor.author | Sitges Carreño, Marta |
| dc.contributor.author | Mont Girbau, Lluís |
| dc.contributor.author | Guasch i Casany, Eduard |
| dc.contributor.author | Egea Guri, Gustavo |
| dc.date | 2017-10-06T16:33:14Z |
| dc.date | 2017-10-06T16:33:14Z |
| dc.date | 2017-09-25 |
| dc.date | 2017-10-06T16:33:14Z |
| dc.identifier | 2047-9980 |
| dc.identifier | 673623 |
| dc.identifier | 28947563 |
| dc.identifier.uri | http://hdl.handle.net/2445/116287 |
| dc.description | BACKGROUND: Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long-term dynamic exercise of moderate intensity on the MF cardiovascular phenotype. METHODS AND RESULTS: In a transgenic mouse model of MF (Fbn1C1039G/+), 4-month-old wild-type and MF mice were subjected to training on a treadmill for 5 months; sedentary littermates served as controls for each group. Aortic and cardiac remodeling was assessed by echocardiography and histology. The 4-month-old MF mice showed aortic root dilatation, elastic lamina rupture, and tunica media fibrosis, as well as cardiac hypertrophy, left ventricular fibrosis, and intramyocardial vessel remodeling. Over the 5-month experimental period, aortic root dilation rate was significantly greater in the sedentary MF group, compared with the wild-type group (∆mm, 0.27±0.07 versus 0.13±0.02, respectively). Exercise significantly blunted the aortic root dilation rate in MF mice compared with sedentary MF littermates (∆mm, 0.10±0.04 versus 0.27±0.07, respectively). However, these 2 groups were indistinguishable by aortic root stiffness, tunica media fibrosis, and elastic lamina ruptures. In MF mice, exercise also produced cardiac hypertrophy regression without changes in left ventricular fibrosis. CONCLUSIONS: Our results in a transgenic mouse model of MF indicate that moderate dynamic exercise mitigates the progression of the MF cardiovascular phenotype. |
| dc.format | 26 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1161/JAHA.117.006438 |
| dc.relation | Journal Of The American Heart Association, 2017, vol. 6, num. 9, p. e006438 |
| dc.relation | https://doi.org/10.1161/JAHA.117.006438 |
| dc.rights | cc-by-nc (c) Mas-Stachurska, Aleksandra et al., 2017 |
| dc.rights | http://creativecommons.org/licenses/by-nc/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Malalties hereditàries |
| dc.subject | Exercici |
| dc.subject | Aneurismes aòrtics |
| dc.subject | Models animals en la investigació |
| dc.subject | Genetic diseases |
| dc.subject | Exercise |
| dc.subject | Aortic aneurysms |
| dc.subject | Animal models in research |
| dc.title | Cardiovascular benefits of moderate exercise training in Marfan syndrome: Insights from an animal model. |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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