Title:
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Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy
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Author:
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Luque Gómez, Ana; Farwati, Abduljalil; Crovetto, Francesca; Crispi Brillas, Fàtima; Figueras Retuerta, Francesc; Gratacós Solsona, Eduard; Aran Perramon, Josep M.
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Notes:
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To assess the usefulness of circulating microRNAs (miRNAs) as non-invasive molecular biomarkers for early prediction of preeclampsia, a differential miRNA profiling analysis was performed in first-trimester pooled sera from 31 early preeclampsia patients, requiring delivery before 34 weeks of gestation, and 44 uncomplicated pregnancies using microfluidic arrays. Among a total of 754 miRNAs analyzed, the presence of 63 miRNAs (8%) was consistently documented in the sera from preeclampsia and control samples. Nevertheless, only 15 amplified miRNAs (2%) seemed to be differentially, although modestly, represented (fold change range: 0.4-1.4). After stem loop RT-qPCR from individual samples, the statistical analysis confirmed that none of the most consistent and differentially represented miRNAs (3 overrepresented and 4 underrepresented) were differentially abundant in serum from preeclamptic pregnancies compared with serum from normal pregnancies. Therefore, maternal serum miRNA assessment at first-trimester of pregnancy does not appear to have any predictive value for early preeclampsia. |
Subject(s):
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-Hipertensió en l'embaràs -Micro RNAs -Hypertension in pregnancy -MicroRNAs |
Rights:
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cc-by (c) Luque Gómez, Ana et al., 2014
http://creativecommons.org/licenses/by/3.0/es
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Document type:
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Article Article - Published version |
Published by:
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Nature Publishing Group
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