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| dc.contributor.author | Luque Gómez, Ana |
|---|---|
| dc.contributor.author | Farwati, Abduljalil |
| dc.contributor.author | Crovetto, Francesca |
| dc.contributor.author | Crispi Brillas, Fàtima |
| dc.contributor.author | Figueras Retuerta, Francesc |
| dc.contributor.author | Gratacós Solsona, Eduard |
| dc.contributor.author | Aran Perramon, Josep M. |
| dc.date | 2018-11-08T14:40:06Z |
| dc.date | 2018-11-08T14:40:06Z |
| dc.date | 2014-05-08 |
| dc.date | 2018-11-08T14:40:07Z |
| dc.identifier | 2045-2322 |
| dc.identifier | 677834 |
| dc.identifier | 24811064 |
| dc.identifier.uri | http://hdl.handle.net/2445/125922 |
| dc.description | To assess the usefulness of circulating microRNAs (miRNAs) as non-invasive molecular biomarkers for early prediction of preeclampsia, a differential miRNA profiling analysis was performed in first-trimester pooled sera from 31 early preeclampsia patients, requiring delivery before 34 weeks of gestation, and 44 uncomplicated pregnancies using microfluidic arrays. Among a total of 754 miRNAs analyzed, the presence of 63 miRNAs (8%) was consistently documented in the sera from preeclampsia and control samples. Nevertheless, only 15 amplified miRNAs (2%) seemed to be differentially, although modestly, represented (fold change range: 0.4-1.4). After stem loop RT-qPCR from individual samples, the statistical analysis confirmed that none of the most consistent and differentially represented miRNAs (3 overrepresented and 4 underrepresented) were differentially abundant in serum from preeclamptic pregnancies compared with serum from normal pregnancies. Therefore, maternal serum miRNA assessment at first-trimester of pregnancy does not appear to have any predictive value for early preeclampsia. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Nature Publishing Group |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1038/srep04882 |
| dc.relation | Scientific Reports, 2014, vol. 4 |
| dc.relation | https://doi.org/10.1038/srep04882 |
| dc.rights | cc-by (c) Luque Gómez, Ana et al., 2014 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Hipertensió en l'embaràs |
| dc.subject | Micro RNAs |
| dc.subject | Hypertension in pregnancy |
| dc.subject | MicroRNAs |
| dc.title | Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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