Universitat de Barcelona
Berndt, Sonja I.
Skibola, Christine F.
Joseph, Vijai
Camp, Nicola J.
Nieters, Alexandra
Wang, Zhaoming
Cozen, Wendy
Monnereau, Alain
Wang, Sophia S.
Kelly, Rachel S.
Lan, Qing
Teras, Lauren R.
Chatterjee, Nilanjan
Chung, Charles C.
Yeager, Meredith
Brooks-Wilson, Angela R.
Hartge, Patricia
Purdue, Mark P.
Birmann, Brenda M.
Armstrong, Bruce K.
Cocco, Pierluigi
Zhang, Yawei
Severi, Gianluca
Zeleniuch-Jacquotte, Anne
Lawrence, Charles
Burdette, Laurie
Yuenger, Jeffrey
Hutchinson, Amy
Jacobs, Kevin B.
Call, Timothy G.
Shanafelt, Tait D.
Novak, Anne J.
Kay, Neil E.
Liebow, Mark
Wang, Alice H.
Smedby, Karin E.
Adami, Hans-Olov
Melbye, Mads
Glimelius, Bengt
Chang, Ellen T.
Glenn, Martha
Curtin, Karen
Cannon-Albright, Lisa A.
Jones, Brandt
Diver, W. Ryan
Link, Brian K.
Weiner, George J.
Conde, Lucía
Bracci, Paige M.
Riby, Jacques
Holly, Elizabeth A.
Smith, Martyn T.
Jackson, Rebecca D. J.
Tinker, Lesley F.
Benavente, Yolanda
Becker, Nikolaus
Boffetta, Paolo
Brennan, Paul
Foretova, Lenka
Maynadié, Marc
McKay, James D.
Staines, Anthony
2018-11-12T15:44:17Z
2018-11-12T15:44:17Z
2013-01-01
2018-11-12T15:44:17Z
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.
English
Leucèmia limfocítica crònica; Genòmica; Chronic lymphocytic leukemia; Genomics
Nature Publishing Group
Versió postprint del document publicat a: https://doi.org/10.1038/ng.2652
Nature Genetics, 2013, vol. 8, num. 45, p. 868-876
https://doi.org/10.1038/ng.2652
(c) Springer Nature, 2013
