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Título:	Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals
Autor/a:	López Vicario, Cristina; Rius, Bibiana; Alcaraz-Quiles, José; González Périz, Ana; Martinez Puchol, Ana Isabel; Casulleras, Mireia; Duran Güell, Marta; Ibarzabal, Ainitze; Corcelles Codina, Ricard; Laguna Fernández, Andrés; Bäck, Magnus; Titos Rodríguez, Esther; Clària i Enrich, Joan
Notas:	Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1 beta, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-alpha 2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.
Materia(s):	-Teixit adipós -Obesitat mòrbida -Inflamació -Comorbiditat -Polimorfisme genètic -Adipose tissues -Morbid obesity -Inflammation -Comorbidity -Genetic polymorphisms
Derechos:	cc-by (c) López-Vicario, Cristina et al., 2017 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Nature Publishing Group
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