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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/138621

dc.contributor.author Clària i Enrich, Joan
dc.contributor.author González Périz, Ana
dc.contributor.author López Vicario, Cristina
dc.contributor.author Rius, Bibiana
dc.contributor.author Titos Rodríguez, Esther
dc.date 2019-08-01T14:13:14Z
dc.date 2019-08-01T14:13:14Z
dc.date 2011-11-05
dc.date 2019-08-01T14:13:14Z
dc.identifier 1664-3224
dc.identifier 627768
dc.identifier 22566839
dc.identifier.uri http://hdl.handle.net/2445/138621
dc.description Obesity is causally linked to a chronic state of 'low-grade' inflammation in adipose tissue. Prolonged, unremitting inflammation in this tissue has a direct impact on insulin-sensitive tissues (i.e., liver) and its timely resolution is a critical step toward reducing the prevalence of related co-morbidities such as insulin resistance and non-alcoholic fatty liver disease. This article describes the current state-of-the-art knowledge and novel insights into the role of macrophages in adipose tissue inflammation, with special emphasis on the progressive changes in macrophage polarization observed over the course of obesity. In addition, this article extends the discussion to the contribution of Kupffer cells, the liver resident macrophages, to metabolic liver disease. Special attention is given to the modulation of macrophage responses by omega-3-PUFAs, and more importantly by resolvins, which are potent anti-inflammatory and pro-resolving autacoids generated from docosahexaenoic and eicosapentaenoic acids. In fact, resolvins have been shown to work as endogenous 'stop signals' in inflamed adipose tissue and to return this tissue to homeostasis by inducing a phenotypic switch in macrophage polarization toward a pro-resolving phenotype. Collectively, this article offers new views on the role of macrophages in metabolic disease and their modulation by endogenously generated omega-3-PUFA-derived lipid mediators.
dc.format 8 p.
dc.format application/pdf
dc.language eng
dc.publisher Frontiers Media
dc.relation Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2011.00049
dc.relation Frontiers in Immunology, 2011, vol. 2
dc.relation https://doi.org/10.3389/fimmu.2011.00049
dc.rights cc-by (c) Clària i Enrich, Joan et al., 2011
dc.rights http://creativecommons.org/licenses/by/3.0/es
dc.rights info:eu-repo/semantics/openAccess
dc.subject Teixit adipós
dc.subject Àcids grassos omega-3
dc.subject Macròfags
dc.subject Inflamació
dc.subject Adipose tissues
dc.subject Omega-3 fatty acids
dc.subject Macrophages
dc.subject Inflammation
dc.title New insights into the role of macrophages in adipose tissue inflammation and fatty liver disease: modulation by endogenous omega-3 fatty acid-derived lipid mediators
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion

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