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| dc.contributor.author | Almendros López, Isaac |
|---|---|
| dc.contributor.author | Carreras, Alba |
| dc.contributor.author | Montserrat Canal, José Ma. |
| dc.contributor.author | Gozal, David |
| dc.contributor.author | Navajas Navarro, Daniel |
| dc.contributor.author | Farré Ventura, Ramon |
| dc.date | 2019-08-02T14:25:12Z |
| dc.date | 2019-08-02T14:25:12Z |
| dc.date | 2012-07-11 |
| dc.date | 2019-08-02T14:25:13Z |
| dc.identifier | 1664-2295 |
| dc.identifier | 630101 |
| dc.identifier | 22807922 |
| dc.identifier.uri | http://hdl.handle.net/2445/138678 |
| dc.description | Adult stem cells are undifferentiated cells that can be mobilized from the bone marrow or other organs, home into injured tissues, and differentiate into different cell phenotypes to serve in a repairing capacity. Furthermore, these cells can respond to inflammation and oxidative stress by exhibiting immunomodulatory properties. The protective and reparative roles of mesenchymal stem cells (MSCs), very small embryonic-like stem cells (VSELs), and endothelial progenitor cells (EPCs) have primarily been examined and characterized in auto-immune and cardiovascular diseases. Obstructive sleep apnea (OSA) is a very prevalent disease (4-5% of adult population and 2-3% of children) characterized by an abnormal increase in upper airway collapsibility. Recurrent airway obstructions elicit arterial oxygen desaturations, increased inspiratory efforts, and sleep fragmentation, which have been associated with important long-term neurocognitive, metabolic, and cardiovascular consequences. Since inflammation, oxidative stress and endothelial dysfunction are key factors in the development of the morbid consequences of OSA, bone marrow-derived stem cells could be important modulators of the morbid phenotype by affording a protective role. This mini-review is focused on the recent data available on EPCs, VSELs, and MSCs in both animal models and patients with OSA. |
| dc.format | 6 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Frontiers Media |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.3389/fneur.2012.00112 |
| dc.relation | Frontiers In Neurology, 2012, vol. 3 |
| dc.relation | https://doi.org/10.3389/fneur.2012.00112 |
| dc.rights | cc-by (c) Almendros López, Isaac et al., 2012 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Síndromes d'apnea del son |
| dc.subject | Cèl·lules mare |
| dc.subject | Sleep apnea syndromes |
| dc.subject | Stem cells |
| dc.title | Potential role of adult stem cells in obstructive sleep apnea |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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