The associations between oxytocin and trauma in humans: A systematic review

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

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dc.contributor.author	Fortunata Donadon, Mariana
dc.contributor.author	Martín-Santos Laffon, Rocío
dc.contributor.author	Lima Osório, Flávia de
dc.date	2019-09-18T10:32:46Z
dc.date	2019-09-18T10:32:46Z
dc.date	2018-03-01
dc.date	2019-09-18T10:32:46Z
dc.identifier	1663-9812
dc.identifier	680294
dc.identifier	29545749
dc.identifier.uri	http://hdl.handle.net/2445/140385
dc.description	Studies have shown that traumatic experiences may affect hormonal systems mediated by the hypothalamic-pituitary-adrenal (HPA) axis and the oxytocinergic system. This effect is the result of long-term impairments in hypothalamic structures and negative feedback mechanisms within the HPA axis, structures that mediate the response to stress. This deregulation reduces the production and release of cortisol and oxytocin (OXT), which may alter stress responses and lead to increased vulnerability to impairments from stressful experiences. The presence of gene polymorphisms might also have an impact on the vulnerability to psychopathology. We made a systematic review of articles dealing with the relationship between OXT and traumatic emotional experiences in humans. Thirty-five studies were reviewed and significant associations between experiences of emotional trauma (ET) and OXT were found. The main results showed that the presence of ET and post-traumatic stress disorder (PTSD) is strongly associated with reductions in endogenous OXT, and also that the acute effects of OXT administrations in individuals with ET tend to be anxiolytic only in less severe forms. In victims of recent traumatic experiences (RTE), OXT increased the re-experience of traumas and restored the function of different neural networks associated with fear control/extinction in PTSD patients. The results available also suggest that gene receptor polymorphisms may have a protective function in different outcomes after the experience of traumatic events. We conclude that the relationship between ET and OXT is multifaceted, complex, and mediated by contextual and individual factors. Directions for future studies are suggested considering the gaps in the available literature.
dc.format	16 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	Frontiers Media
dc.relation	Reproducció del document publicat a: https://doi.org/10.3389/fphar.2018.00154
dc.relation	Frontiers in Pharmacology, 2018, vol. 9, p. 154
dc.relation	https://doi.org/10.3389/fphar.2018.00154
dc.rights	cc-by (c) Fortunata Donadon, Mariana et al., 2018
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Oxitocina
dc.subject	Traumes psíquics
dc.subject	Ressenyes sistemàtiques (Investigació mèdica)
dc.subject	Oxytocin
dc.subject	Psychic trauma
dc.subject	Systematic reviews (Medical research)
dc.title	The associations between oxytocin and trauma in humans: A systematic review
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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