Universitat de Barcelona
2019-10-28T17:49:39Z
2019-10-28T17:49:39Z
2014
2019-10-28T17:49:39Z
The iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N‐tosylaziridines reported previously. The commercially available threonine‐derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β‐methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY‐404187.
Article
Versió publicada
Anglès
Lipofília; Química farmacèutica; Lipophilicity; Pharmaceutical chemistry
IAPC Publishing
Reproducció del document publicat a: https://doi.org/10.5599/admet.2.2.45
ADMET & DMPK, 2014, vol. 2, num. 2, p. 107-114
https://doi.org/10.5599/admet.2.2.45
cc-by (c) Pallicer Santana, Juan Manuel et al., 2014
http://creativecommons.org/licenses/by/3.0/es
