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Título:	Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
Autor/a:	Cillóniz, Catia; Dominedò, Cristina; Ielpo, Antonella; Ferrer Monreal, Miquel; Gabarrús, Albert; Battaglini, Denise; Bermejo Martín, Jesús; Meli, Andrea; Garcia Vidal, Carolina; Liapikou, Adamantia; Singer, Mervyn; Torres Martí, Antoni
Notas:	Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4219 patients hospitalized with CAP during the study period, 1238 (29%) were very old. The prevalence of sepsis in this age group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.
Materia(s):	-Pneumònia adquirida a la comunitat -Septicèmia -Persones grans -Community-acquired pneumonia -Septicemia -Older people
Derechos:	cc by (c) Cillóniz et al., 2019 http://creativecommons.org/licenses/by/3.0/es/
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	MDPI
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