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| dc.contributor.author | Urra, Xabier |
|---|---|
| dc.contributor.author | Ariño, Helena |
| dc.contributor.author | Llull, Laura |
| dc.contributor.author | Amaro, Sergio |
| dc.contributor.author | Obach, Víctor |
| dc.contributor.author | Cervera Álvarez, Álvaro |
| dc.contributor.author | Chamorro Sánchez, Ángel |
| dc.date | 2020-01-29T14:30:22Z |
| dc.date | 2020-01-29T14:30:22Z |
| dc.date | 2013-03-19 |
| dc.date | 2020-01-29T14:30:22Z |
| dc.identifier | 1932-6203 |
| dc.identifier | http://hdl.handle.net/2445/148918 |
| dc.identifier | 690628 |
| dc.identifier.uri | http://hdl.handle.net/2445/148918 |
| dc.description | Introduction: In up to one third of patients with mild stroke suitable to receive systemic thrombolysis the treatment is not administered because the treating physicians estimate a good spontaneous recovery. However, it is not settled whether the fate of these patients is equivalent to those who are thrombolysed. Methods: We analyzed 203 consecutive patients (134 men and 69 women, mean age 69614 years) without premorbid disability and a NIHSS score #5 at admission [median 3 (IQR 2-4)]. Intravenous thrombolysis was administered within 4.5 hours from stroke onset (n = 119), or it was withheld (n = 84) whenever the treating physician predicted a spontaneous recovery. The baseline risk factors, clinical course, infarction volume, bleeding complications, and functional outcome at 3 months were analyzed and declared to a Web-based registry which was accessible to the local Health Authorities. Results: Expectedly, not thrombolysed patients had the mildest strokes at admission [median 2 (IQR 1-3.75)]. At day 2 to 5, the infarct volume on DWI-MRI was similar in both groups. There were no symptomatic cerebral bleedings in the study. An ordinal regression model adjusted for baseline stroke severity showed that thrombolysis was associated with a greater proportion of patients who shifted down on the modified Rankin Scale score at 3 months (OR 2.66; 95% CI 1.49-4.74, p = 0.001). Conclusions: Intravenous thrombolysis seems to be safe in patients with mild stroke and may be associated with improved outcome compared with untreated patients. These results sup |
| dc.format | 5 p. |
| dc.format | application/pdf |
| dc.language | spa |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0059420 |
| dc.relation | PLoS One, 2013, vol. 8, num. 3, p. e59420 |
| dc.relation | https://doi.org/10.1371/journal.pone.0059420 |
| dc.rights | cc-by (c) Urra, Xabier et al., 2013 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Isquèmia cerebral |
| dc.subject | Malalties cerebrovasculars |
| dc.subject | Hemorràgia |
| dc.subject | Cerebral ischemia |
| dc.subject | Cerebrovascular disease |
| dc.subject | Hemorrhage |
| dc.title | The Outcome of Patients with Mild Stroke Improves after Treatment with Systemic Thrombolysis |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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