Universitat de Barcelona
2020-05-14T08:55:38Z
2020-05-14T08:55:38Z
2018-03-01
2020-05-14T08:55:38Z
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid:oleic acid ratio impacts diabetes risk in humans. Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve β cell survival. Understanding the molecular mechanisms of the antidiabetic effects of oleic acid may contribute to understanding the benefits of this FA in the prevention or delay of T2DM.
Article
Versió acceptada
Anglès
Àcid oleic; Resistència a la insulina; Inflamació; Diabetis no-insulinodependent; Obesitat; Oleic acid; Insulin resistance; Inflammation; Non-insulin-dependent diabetes; Obesity
Elsevier Current Trends
Versió postprint del document publicat a: https://doi.org/10.1016/j.tem.2017.11.009
Trends in Endocrinology and Metabolism, 2018, vol. 29, num. 3, p. 178-190
https://doi.org/10.1016/j.tem.2017.11.009
cc-by-nc-nd (c) Elsevier Current Trends, 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es
