Over the past ten years several learning environments based on novel interaction modalities have been developed. Within this field, Full-body Interaction Learning Environments open promising possibilities given their capacity to involve the users at different levels, such as sensorimotor experience, cognitive aspects and affective factors. However, Full-body Interaction is still a young field and research on design and assessment methods offers a fragmented panorama from which it is not possible to derive clear research solutions. Starting from this necessity, we present a systematic review of educational applications developed as Full-body Interaction and the results of their empirical evaluation. Our analysis offers instruments to systematize the multiple aspects involved in the design and assessment of Full-body Interaction Learning Environments and provides guidelines for novel research paths.