Title:
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Copper-mediated SN2’ Allyl-Alkyl and Allyl-Boryl Couplings of Vi- nyl Cyclic Carbonates
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Author:
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Miralles, Núria; Gómez, José Enrique; Kleij, Arjan W.; Fernández, Elena
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Abstract:
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A method for the copper-catalyzed borylmethylation and borylation of vinyl cyclic carbonates through an SN2’ mech- anism is reported. These singular reactions involve selective SN2’ allylic substitutions with concomitant ring opening of the cyclic carbonate, and with extrusion of CO2 and formation of a useful hydroxyl functionality in a single step. The stereoselectivity of the homoallylic borylation and allylic borylation processes can be controlled, and synthetically useful unsaturated (E)-pent-2-ene-1,5- diols and (E)-but-2-ene-1,4-diols accessed. |
Publication date:
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2017-10-27 |
Subject(s):
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54 |
Rights:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Pages:
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6096 p. |
Document type:
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Article Article - Accepted version |
DOI:
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10.1021/acs.orglett.7b02947
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