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Title:
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Cardiovascular benefits of moderate exercise training in Marfan syndrome: Insights from an animal model.
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Author:
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Mas-Stachurska, Aleksandra; Siegert, Anna-Maria Elisa; Batlle, Montserrat; Gorbenko del Blanco, Darya; Meirelles, Thayna; Rubies, Cira; Bonorino, Fabio; Serra-Peinado, Carla; Bijnens, Bart; Baudin, Julio; Sitges Carreño, Marta; Mont Girbau, Lluís; Guasch i Casany, Eduard; Egea Guri, Gustavo
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Notes:
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BACKGROUND: Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long-term dynamic exercise of moderate intensity on the MF cardiovascular phenotype. METHODS AND RESULTS: In a transgenic mouse model of MF (Fbn1C1039G/+), 4-month-old wild-type and MF mice were subjected to training on a treadmill for 5 months; sedentary littermates served as controls for each group. Aortic and cardiac remodeling was assessed by echocardiography and histology. The 4-month-old MF mice showed aortic root dilatation, elastic lamina rupture, and tunica media fibrosis, as well as cardiac hypertrophy, left ventricular fibrosis, and intramyocardial vessel remodeling. Over the 5-month experimental period, aortic root dilation rate was significantly greater in the sedentary MF group, compared with the wild-type group (∆mm, 0.27±0.07 versus 0.13±0.02, respectively). Exercise significantly blunted the aortic root dilation rate in MF mice compared with sedentary MF littermates (∆mm, 0.10±0.04 versus 0.27±0.07, respectively). However, these 2 groups were indistinguishable by aortic root stiffness, tunica media fibrosis, and elastic lamina ruptures. In MF mice, exercise also produced cardiac hypertrophy regression without changes in left ventricular fibrosis. CONCLUSIONS: Our results in a transgenic mouse model of MF indicate that moderate dynamic exercise mitigates the progression of the MF cardiovascular phenotype. |
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Subject(s):
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-Malalties hereditàries
-Exercici
-Aneurismes aòrtics
-Models animals en la investigació
-Genetic diseases
-Exercise
-Aortic aneurysms
-Animal models in research |
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Rights:
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cc-by-nc (c) Mas-Stachurska, Aleksandra et al., 2017
http://creativecommons.org/licenses/by-nc/3.0/es
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Document type:
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Article
Article - Published version |
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