Ni-catalyzed Direct Reductive Amidation via C−O Bond Cleavage

Abstract

<p> &nbsp;</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> A novel Ni-catalyzed reductive amidation</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> of C(sp<span style="font: 7.0px 'Times New Roman'">2</span>)&minus; and C(sp<span style="font: 7.0px 'Times New Roman'">3</span>)&minus;O electrophiles with isocyanates</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> is described. Such umpolung reaction allows for an unconventional</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> preparation of benzamides by using simple</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> starting materials and easy-to-handle Ni catalysts.</p> <p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.5px 'Times New Roman'"> Within</p>