dc.contributor.author |
Gómez, José Enrique |
dc.contributor.author |
Guo, Wusheng |
dc.contributor.author |
Gaspa, Silvia |
dc.contributor.author |
Kleij, Arjan W. |
dc.date.accessioned |
2019-05-22T14:58:51Z |
dc.date.available |
2019-05-22T14:58:51Z |
dc.date.issued |
2017-11-20 |
dc.identifier.uri |
http://hdl.handle.net/2072/356063 |
dc.format.extent |
15035 p. |
dc.language.iso |
eng |
dc.rights |
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source |
RECERCAT (Dipòsit de la Recerca de Catalunya) |
dc.subject.other |
54 |
dc.title |
Copper-Catalyzed Synthesis of -Amino Acids Featuring Quaternary Stereocenters |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.embargo.terms |
12 mesos |
dc.identifier.doi |
10.1002/anie.201709511 |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
The first general asymmetric synthesis of -disubstituted -amino acids via Cu-catalyzed ring opening of non-strained lactones with amines is reported. This approach features ample scope, operational simplicity and wide functional group diversity. The catalytic process allows to access a series of highly functionalized enantioenriched -amino acids featuring quaternary stereocenters with excellent enantiomeric ratios up to 98:2 and excellent yields up to 98%. |