Patologia i Terapèutica Experimental: Enviaments recents
Ara mostrant els elements 1-20 de 1064
Identification and evaluation of novel intergenic sites in the vaccinia virus genome for transgene insertion
Vaccinia virus (VACV) is widely used as a vaccine and oncolytic vector due to its safety profile and its capacity to accommodate exogenous DNA. However, its compact genome offers limited for transgene insertion without ...
Loss-of-function genetic screen unveils synergistic efficacy of PARG inhibition with combined 5-fluorouracil and irinotecan treatment in colorectal cancer
Background: Colorectal cancer (CRC) remains a major global health concern, partly due to resistance to therapy and the lack of new effective treatments for advanced disease. The combination of 5-Fluorouracil (5FU, a ...
Silver-coated silicone stents as an approach to prevent bacterial colonization of central airways after tracheobronchial stenting.
Rationale: Tracheobronchial stents are used to treat central airway obstruction but frequently develop bacterial colonization that can lead to infection.Objectives: To identify the microorganisms responsible for stent ...
Future prospects for Antimicrobial peptide development: peptidomimetics and antimicrobial combinations
Antimicrobial resistance is widely recognized as one of the major challenges of public health worldwide, as infections by multidrug-resistant (MDR) bacteria have reached worrisome levels. Three levels of antibiotic resistance ...
Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease
Background: New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising ...
Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning
Dravet syndrome (DS) is a developmental epileptic encephalopathy (DEE) driven by pathogenic variants in the SCN1A gene. Brain organoids (BOs) have emerged as reliable models for neurodevelopmental genetic disorders, ...
Identification of the atypical antipsychotic Asenapine as a direct survivin inhibitor with anticancer properties and sensitizing effects to conventional therapies
Therapy resistance in human cancers is a major limitation in Clinical Oncology. In this regard, overexpression of anti-apoptotic proteins, such as survivin, has been described in several tumors, contributing to this clinical ...
Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo
Purpose: To interrogate animal physiology in vivo, there is a lack of non-genetic methods to control the activity of endogenous proteins with pharmacological and spatiotemporal precision. To address this need, we recently ...
CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness
GATA2 deficiency is a monogenic transcriptopathy disorder characterized by bone marrow failure (BMF), immunodeficiency, and a high risk of developing myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML). Although ...
Intraoperative brain mapping in multilingual patients: what do we know and where are we going?
In this review, we evaluate the knowledge gained so far about the neural bases of multilingual language processing obtained mainly through imaging and electrical stimulation mapping (ESM). We attempt to answer some key ...
Altered resting-state functional connectivity in individuals at risk for Alzheimer’s disease: a longitudinal study
Background: Resting-state functional connectivity magnetic resonance imaging (rs-fMRI) is a sensitive tool for detecting early brain changes associated with Alzheimer's disease, even in its preclinical stages. Amnestic ...
Long-lasting behavioral, molecular and functional connectivity alterations after chronic THC exposure during adolescence in mice
Heavy and daily use of cannabis with high contents of Delta 9-tetrahydrocannabinol (THC) during adolescence is associated with an increased risk of developing psychotic disorders later in life. Here, we treated mice with ...
Circulating endothelial progenitor cell colony-forming capacity in healthy subjects: how does an endothelial colony look like?
We read with great interest the recent report in the American Journal of Cardiology by Hoetzer et al.1 The investigators addressed the question of whether in healthy, middle-aged subjects circulating endothelial progenitor ...
Variations in the course and diameter of the suprascapular nerve: Anatomical study
Suprascapular neuropathy is an important factor contributing to shoulder pain. Given the prevalence of nerve injury and nerve block in the suprascapular notch region, as well as the frequency of arthroscopic procedures on ...
Compartir ideas. La Universidad va al Instituto: un proyecto de aprendizaje- servicio transversal de la Universidad de Barcelona
Compartir ideas. La universidad va al instituto es un proyecto de aprendizaje servicio transversal de la Universidad de Barcelona. Este representa una propuesta de aprendizaje servicio que bajo una estructura común permite ...
Tyrosine phosphorylation of ras GTPase activating protein does not require association with the epidermal growth factor receptor
The importance of the carboxyl-terminal domain of the epidermal growth factor (EGF) receptor and its five autophosphorylation sites in the in vivo interaction and tyrosine phosphorylation of the ras GTPase-activating protein ...
Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of alzheimer disease and identification of lipoxidation targets
Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the amount of structurally characterized probes ...
Evaluation of a new mouthwash formulated with Chlorhexidine and Cymenolafter a scaling and root planing treatment in grade I and II periodontal patients
Background: Periodontal disease (PD) is a chronic inflammatory disease of multifactorial origin that affects the supporting tissues of the tooth. According to WHO in 2022, severe periodontal disease will affect around 19% ...
Phosphoprotein phosphatase 1 isoforms alpha and gamma respond differently to prodigiosin treatment and present alternative kinase targets in melanoma cells
Reversible protein phosphorylation is a central regulatory mechanism of cell function. Deregulation of the balanced actions of protein kinases and phosphatases has been frequently associated with several pathological ...
Repercusiones clínicas de la anorexia nerviosa restrictiva en la cavidad oral
¿Cuáles son los signos de alerta que aparecen en la cavidad oral de los pacientes con trastornos de la conducta alimentaria? Factores biológicos como la edad, el sexo, el balance hormonal o la osteoporosis, aparte de ...
