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| dc.contributor.author | Martín Cardona, Albert |
|---|---|
| dc.contributor.author | Fernández Esparrach, Glòria |
| dc.contributor.author | Subtil, J. C. |
| dc.contributor.author | Iglesias García, J. |
| dc.contributor.author | García Guix, Marta |
| dc.contributor.author | Barturen Barroso, A. |
| dc.contributor.author | Gimeno García, A. Z. |
| dc.contributor.author | Esteban, J. M. |
| dc.contributor.author | Pardo Balteiro, A. |
| dc.contributor.author | Velasco Guardado, A. |
| dc.contributor.author | Vázquez-Sequeiros, Enrique |
| dc.contributor.author | Loras Alastruey, Carme |
| dc.contributor.author | Martínez Moreno, B. |
| dc.contributor.author | Castellot, A. |
| dc.contributor.author | Huertas, Carlos |
| dc.contributor.author | Martínez Lapiedra, M. |
| dc.contributor.author | Sánchez Yagüe, Andrés |
| dc.contributor.author | Terán, A. |
| dc.contributor.author | Morales Alvarado, Víctor Jair |
| dc.contributor.author | Betes, M. |
| dc.contributor.author | Iglesia, D. de la |
| dc.contributor.author | Sánchez Montes, Cristina |
| dc.contributor.author | Lozano, Maria Dolores |
| dc.contributor.author | Lariño Noia, J. |
| dc.contributor.author | Ginés, A. |
| dc.contributor.author | Tebé, Cristian |
| dc.contributor.author | Gornals Soler, Joan B. |
| dc.contributor.author | Spanish Group for EUS-Guided TA in the adrenal gland |
| dc.date | 2020-01-29T15:06:46Z |
| dc.date | 2020-01-29T15:06:46Z |
| dc.date | 2019-06-06 |
| dc.date | 2020-01-29T15:06:46Z |
| dc.identifier | 1932-6203 |
| dc.identifier | http://hdl.handle.net/2445/148922 |
| dc.identifier | 690471 |
| dc.identifier.uri | http://hdl.handle.net/2445/148922 |
| dc.description | Background: There are limited data about the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA), by fine needle aspiration (EUS-FNA) or biopsy (EUS-FNB), in the evaluation of the adrenal glands (AG). The primary aim was to assess the diagnostic yield and safety. The secondary aims were the malignancy predictors, and to create a predictive model of malignancy. Methods: This was a retrospective nationwide study involving all Spanish hospitals experienced in EUS-TA of AGs. Inclusion period was from April-2003 to April-2016. Inclusion criteria: all consecutive cases that underwent EUS-TA of AGs. EUS and cytopathology findings were evaluated. Statistical analyses: diagnostic accuracy of echoendoscopist's suspicion using cytology by EUS-TA, as gold standard; multivariate logistic regression model to predict tumor malignancy. Results: A total of 204 EUS-TA of AGs were evaluated. Primary tumor locations were lung70%, others19%, and unknown11%. AG samples were adequate for cytological diagnosis in 91%, and confirmed malignancy in 60%. Diagnostic accuracy of the endosonographer's suspicion was 68%. The most common technique was: a 22-G (65%) and cytological needle (75%) with suction-syringe (66%). No serious adverse events were described. The variables most associated with malignancy were size>30mm (OR2.27; 95%CI, 1.16-4.05), heterogeneous echo-pattern (OR2.11; 95%CI, 1.1-3.9), variegated AG shape (OR2.46; 95%CI, 1-6.24), and endosonographer suspicion (OR17.46; 95%CI, 6.2-58.5). The best variables for a predictive multivariate logistic model of malignancy were age, sex, echo-pattern, and AG-shape. Conclusions: EUS-TA of the AGs is a safe, minimally invasive procedure, allowing an excellent diagnostic yield. These results suggest the possibility of developing a pre-EUS procedure predictive malignancy model. |
| dc.format | 16 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0216658 |
| dc.relation | PLoS One, 2019, vol. 14, num. 6, p. e0216658 |
| dc.relation | https://doi.org/10.1371/journal.pone.0216658 |
| dc.rights | cc-by (c) Martín Cardona, Albert et al., 2019 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Diagnòstic |
| dc.subject | Càncer |
| dc.subject | Endoscòpia |
| dc.subject | Diagnosis |
| dc.subject | Cancer |
| dc.subject | Endoscopy |
| dc.title | EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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